I’m reading “Cell” by Stephen King and the premise of the book is that anyone who listens to their cell phone within a certain time is driven very insane. So those who were lucky enough not to have cell phones aren’t that lucky after all, because they’re living out the end of the world. The books a great read and I’m not quite half way through it but I was wondering if anyone’s ever tried running a Doomsday campaign.
So to take Stephen King’s other book, “The Stand,” you could have some nasty disease that only affects humans and humanoids so you have an end of the world type of feel. Things get pretty desolate and very wild, cities are shells of what they used to be, that kind of thing. New monsters take over, but a very small percentage of humanoids have a natural resistance so they get to live through the nightmare.
This would be more typical of a modern d20 campaign, but you could do it in a D&D setting as well.